Communications - Scientific Letters of the University of Zilina 2016, 18(11):13-20 | DOI: 10.26552/com.C.2016.1A.13-20

Object-In-Fluid Framework in Modeling of Blood Flow in Microfluidic Channels

Ivan Cimrak1, Katarina Bachrata1, Hynek Bachraty1, Iveta Jancigova2, Renata Tothova1, Martin Busik1, Martin Slavik1, Markus Gusenbauer3
1 Department of Software Technologies, Faculty of Management Science and Informatics, University of Zilina, Slovakia and Cell-in-Fliud Research Group, Slovakia
2 Department of Mathematical Methods and Operations Research, Faculty of Management Science and Informatics, University of Zilina, Slovakia and Cell-in-Fliud Research Group, Slovakia
3 Center for Integrated Sensor Systems, Danube University Krems, Austria and Cell-in-Fliud Research Group, Slovakia

We present a fully three-dimensional computational model of red blood cells and their flow in a fluid. This model includes all components necessary to capture important physical and biological aspects of the cell flow. It comprises descriptions of elasticity of the cell membrane, cell-cell interactions, two-way cell-fluid interaction, and adhesion of cell to surfaces.

Using this model, we analyze different processes involving flow of cells. We present the results of ongoing research concerning the development of model for cell adhesion, the analysis of microfluidic devices with periodic obstacle arrays, the optimization of microfluidic connectors and biological process of red blood cells formation from reticulocytes.

Keywords: numerical model; simulation; red blood cell; fluid flow

Published: March 31, 2016  Show citation

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Cimrak, I., Bachrata, K., Bachraty, H., Jancigova, I., Tothova, R., Busik, M., Slavik, M., & Gusenbauer, M. (2016). Object-In-Fluid Framework in Modeling of Blood Flow in Microfluidic Channels. Communications - Scientific Letters of the University of Zilina, 18(1A), 13-20. doi: 10.26552/com.C.2016.1A.13-20
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